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Metaxalone generic cost, but not an effective dose) was administered to patients. The rate of adverse events and the incidence of death were compared in both groups until day 90. A total of 4,892 patients were included in this study. RESULTS: Overall, a non-significant difference was observed in the incidence of death, with 0.02% (95% CI -0.13% to 0.17%) of the placebo group reporting a death, and 0.03% (95% CI drugstore sales tax california -0.10% to 0.21%) of the drug group reporting a death, compared with 0.03% (95% CI -0.12% to 0.18%) of the comparison group (P = 0.13). For adverse events, there was a non-significant difference in the incidence of upper respiratory tract infection with pneumonia (5.21% (95% CI 1.01 to 15.91%) vs. 0.27% (0.03% 0.91%); P = 0.24) and lower respiratory tract infection with pneumonia (5.04% (95% CI 1.02 to 12.54%) vs. 0.27% (0.04% 0.85%); P = 0.30) (P 0.15 excluding death). However, on a relative scale, there was much higher mortality in the drug group upper respiratory tract infection with pneumonia (2.45% (95% CI 1.05% to 4.19%), vs. 1.10% (0.59% 2.73%) in the placebo group, P = 0.03). CONCLUSIONS: This study provides evidence that the pharmacokinetic profile of valganciclovir affects the rates both adverse events and mortality, but has no effect on the incidence of upper respiratory tract infection with pneumonia. These findings are in contradiction to the finding of a significantly increased mortality with valganciclovir therapy compared placebo in previous studies. © 2014 British Association for Psychopharmacology.
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