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Mebendazole dosage for humans and the possible role in management and treatment of leprosy (AAP News Release (PDF, 1.6Mb)). "The research also sheds some light on how effective treatments are," said Dr. Bruce Green of the University Rochester. "Leprosy still takes an enormous toll on people living with it today. While this small study may offer some hints, we still have much to learn about leprosy treatment and prevention." To develop a regimen deliver single dose of omalizumab, the team treated 11 patients with omalizumab, either alone or in combination Ambien 5mg 120 $265.00 $2.21 with rituximab. addition, they performed post-trial evaluation to evaluate response and tolerability. The study involved three doses of omalizumab: Single dose: 10 mg IV Double dose: 25 mg IV and 5 IM Triple dose: 50 mg IM and 10 IV "We found that the efficacy of omalizumab was not affected by the type of infusion or duration treatment," said study principal investigator Dr. Dora Adhikari, M.P.H., clinical professor at Duke University School of Medicine. "Overall, omalizumab provided sustained response. was highly effective in our treatment groups and safe in all treated patients." The single dose regimen delivered an impressive response rate compared to omalizumab single dose and IV dosing studies. In the double dose and IV dosing studies, there was only a small difference in response to omalizumab. "The single dose regimen seems feasible and could be a promising alternative to standard therapy for patients with leprosy who cannot use oral medications, which have their own risks," said Dr. Robert Green, a professor of clinical molecular virology at New York University Medical Center. This study is the first to evaluate omalizumab dose-finding in individuals who have already begun therapy for leprosy. It also provides insight for clinical studies involving the administration of multiple drugs and doses for the optimization of drug therapy. "With new antimicrobial treatments like rituximab, the need for a better treatment regimen remains," said Dr. Adhikari. "Our study suggests that omalizumab has a role, which could be combined with other therapies." The team also looked forward to studying omalizumab in combination with standard therapy. This combined approach could include combinations of omalizumab with ritonavir. ### The Duke University Medical Center is a not-for-profit academic medical center whose mission is to transform health worldwide through integrated, collaborative and innovative health care. For more information, visit DukakisMedCenter.org.

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